The sermon "Home Invaders" emphasizes building our lives on a solid foundation and protecting our homes from spiritual invaders. It explores the roles and responsibilities of men and women in the home, highlighting the importance of providing, protecting, and regulating God's image and likeness. The sermon warns against pride and apathy as destructive home invaders. Believers are called to be vigilant and resist these invaders, ensuring that their lives and relationships are grounded in God's truth and protected from destruction.